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While significantly lower GSH:GSSG ratios were not seen using traditionally defined severity phenotypes, lower ratios corresponded to a greater history of exacerbations, lower lung function, and higher FeNO

In UTX-deficient cells, or when the KDM6 inhibitor GSK-J4 inhibits UTX activity, ATF4 and its target genes, including ChaC1, are upregulated

(en) Glutathione, reduced (GSH)

J Hypertens 25:20672073

In addition to its direct antioxidant properties, growing evidence suggests that some of the beneficial effects of vitamin E in cells resides in its ability to regulate gene expression of proteins (30, 31, 139, 349)

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